David Sinclair

Geneticist and professor at Harvard Medical School, where he co-directs the Paul F. Glenn Center for Biology of Aging Research. Author of Lifespan and host of the Lifespan podcast; co-founder of Tally Health. His information-theory-of-aging work made him one of the most-cited voices on NAD+ biology.

A publicly discussed daily regimen of NMN (about 1 g in the morning), resveratrol (about 1 g, taken with yogurt or another fat for absorption), and metformin — cycled with berberine — alongside vitamin D3, vitamin K2, omega-3s, spermidine, quercetin, fisetin, glycine, and low-dose aspirin. Paired with daily intermittent fasting, a mostly plant-based diet, regular exercise, cold exposure, and almost no alcohol. He has increasingly framed this as personalization and biomarker tracking rather than a fixed stack.

Aging treated as a condition with measurable drivers: intervene on the pathways (sirtuins, NAD+, mTOR, AMPK) rather than on individual diseases, and measure the result instead of assuming it. He has said he does not sell the supplements he takes.

@tallyhealth (co-founded — biological-age testing and its supplement line) @lifebiosciences (co-founded — clinical-stage cellular rejuvenation therapies built on partial epigenetic reprogramming)