High-dose vitamin E has been linked to higher all-cause mortality
More is not better. A meta-analysis of 19 trials found that supplementing above ~400 IU/day of vitamin E was associated with a small but measurable increase in all-cause mortality.
The other side of the feed. Sourced, objective reports on what can go wrong, with supplements, protocols, services, and the incentives behind them. A standing reminder to read the research before you commit.
More is not better. A meta-analysis of 19 trials found that supplementing above ~400 IU/day of vitamin E was associated with a small but measurable increase in all-cause mortality.
Two large trials were stopped early after beta-carotene supplementation increased lung cancer incidence and mortality among smokers and asbestos-exposed workers, the opposite of the intended effect.
An analysis of 31 melatonin supplements found actual content ranged from 83% below to 478% above the label, and some contained serotonin. The dose you think you are taking may be off by several-fold.
When a recommendation pays the recommender, the highest-commission option tends to get the loudest endorsement, not the best-evidenced one. Knowing the rough rates helps you read between the lines.
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