Shin-ichiro Imai
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Are you Shin-ichiro Imai? Claim this pagePhysician-scientist and professor of developmental biology and medicine at Washington University in St. Louis, and one of the leading researchers on NAD+ biology and its decline with age.
He proposed the 'NAD World' framework linking NAD+ metabolism, the sirtuin SIRT1, and circadian and neuroendocrine control of aging. His lab showed that SIRT1 in the hypothalamus coordinates aging and longevity across tissues, and that the NAD+ precursor NMN and the enzyme eNAMPT can restore youthful signaling in aged mice.
Aging is, in part, a systemic decline in NAD+ — restoring it, and the sirtuin and hypothalamic signaling it powers, is a route to counter age-associated decline across the whole body.
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The NR supplement actually backed by human trials—boosts NAD+ by over 50%
Tru Niagen's 300mg nicotinamide riboside (NR) is the NAD+ precursor with actual clinical data behind it. Chromadex's patented Niagen® form appears in 65% of registered NR trials. One capsule daily is clinically proven to increase NAD+ levels by over 50% in most people. It's designed for cellular repair and energy, though the mechanism is still being studied—not a magic anti-aging pill.
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