EOD
Submit a findFeedDirectorySign inCaveat emptorFAQFor clinics
Back to the feed
Expert

Leonard Guarente

@leonardguarente·0 finds·0 upvotes earned·0 verifications·0 followers·0 following

This page is maintained by EOD editors. The protocol is compiled from public sources; Leonard Guarente hasn't taken it over yet.

Are you Leonard Guarente? Claim this page
Bio

Novartis Professor of Biology at MIT and director of its Glenn Laboratory for the Science of Aging, and co-founder of Elysium Health. His discovery of the SIR2 gene launched the entire field of sirtuin biology.

Protocol

He was first to identify SIR2 as a gene controlling aging in yeast and to show that sirtuins are NAD+-dependent enzymes — the original link between NAD+ and aging. His work established that the mammalian SIRT1 regulates metabolism and longevity, and that the age-related decline in NAD+ can be countered by precursor supplementation, the basis for Elysium's Basis.

Principles

Sirtuins are guardians of the genome powered by NAD+ — keep NAD+ levels youthful and you keep these repair-and-metabolism enzymes working, a strategy to slow the metabolic decline of aging.

Preferred brands

@elysium (co-founded — NAD+ precursor and longevity supplements)

Finds by @leonardguarente

Nothing submitted yet.

When @leonardguarente shares a find, it'll show up here.

Community finds · the protocol

Submitted by members, independently of Leonard Guarente.
The NR supplement actually backed by human trials—boosts NAD+ by over 50%
0
Supplement$49.00 at Tru Niagen· checked May

The NR supplement actually backed by human trials—boosts NAD+ by over 50%

Tru Niagen's 300mg nicotinamide riboside (NR) is the NAD+ precursor with actual clinical data behind it. Chromadex's patented Niagen® form appears in 65% of registered NR trials. One capsule daily is clinically proven to increase NAD+ levels by over 50% in most people. It's designed for cellular repair and energy, though the mechanism is still being studied—not a magic anti-aging pill.

@curator·1mo ago·0 verified·0 comments
Genex Formulas NMN 1000mg
1
Supplement$59.99· checked May◆ Editor's Pick

Genex Formulas NMN 1000mg

Increased NAD Levels & Healthy Aging. On sale for a dose that does something.

@LZExpert·2mo ago·1 verified·1 comments

See something useful in @leonardguarente's feed? Members can save a find with a single tap.

Join EOD, free

One study + one thing worth trying. Every Sunday.

EOD publishes opinions and summaries of research about supplements, services, and protocols. It is not medical advice. Consult a qualified healthcare provider before changing your supplement, exercise, sleep, or medication regimen.

Some outbound links on EOD are affiliate links. If you buy through them we may earn a small commission, at no extra cost to you. It never influences what we publish or how it's ranked. Full disclosure.

EOD · 123 Placeholder Street, New York, NY 10001

END OF DAY · MMXXVI