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Rx$30.00◆ Editor's Pick
Nurx Azelaic acid 15%
Azelaic acid† is a topical treatment that may be prescribed to treat acne or rosacea. Convenient and affordable prescriptions and tests delivered with free shipping. $30 for 1 month supply.
Evidence
5/5
Multiple RCTs demonstrate efficacy for acne and rosacea. A 2015 meta-analysis found azelaic acid superior to placebo for inflammatory acne lesion reduction and comparable to benzoyl peroxide and tretinoin in head-to-head trials. For rosacea, RCTs show significant improvement in erythema and papulopustules. The evidence base is robust across both indications.
Mechanism
Azelaic acid is a dicarboxylic acid that reduces sebum production, inhibits Cutibacterium acnes (formerly Propionibacterium acnes) growth, and suppresses inflammatory mediators including TNF-α and IL-8. It also has mild tyrosinase inhibition, reducing melanin synthesis, which contributes to its use in hyperpigmentation and rosacea.
Best evidence type
✓
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