Joi + Blokes offers NAD+ (nicotinamide adenine dinucleotide) via subcutaneous injection or nasal spray, dosed monthly. NAD+ is a coenzyme involved in mitochondrial energy production and DNA repair; natural levels decline with age. Requires a consultation and blood draw, with support from board-certified clinicians included.
Multiple RCTs show NMN and NR (NAD+ precursors) improve metabolic markers—insulin sensitivity, muscle function, endothelial function—in small human cohorts. However, direct NAD+ supplementation has minimal human trial data; most evidence comes from precursor compounds, and effect sizes are modest. Replication in larger, longer trials is needed before claiming robust anti-aging benefit.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to cellular energy metabolism and redox reactions. It participates in DNA repair, mitochondrial function, and sirtuin activation—pathways implicated in aging and metabolic health. Oral NAD+ precursors (NMN, NR) aim to replenish intracellular NAD+ pools, which decline with age.
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Observational
“In rodents, obesity and aging impair nicotinamide adenine dinucleotide (NAD+) biosynthesis, which contributes to metabolic dysfunction.”
“Many animal studies have shown that oral administration of the nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide mononucleotide (NMN) prevents the reduction of NAD+ levels in organs and tissues, helping alleviate aging-related”
“The study evaluated how ingestion of nicotinamide mononucleotide (NMN) for 12 weeks by older adults affected blood nicotinamide adenine dinucleotide (NAD +) levels and physical function, particularly walking function.”
“The importance of nicotinamide adenine dinucleotide (NAD+) in human physiology is well recognized.”
Direct oral NAD+ has poor bioavailability and almost no human outcome trials. Most human data is on NMN and NR, not NAD+ itself. RCTs are small (N=20–100), short-term (weeks to months), and often industry-sponsored. No long-term mortality or aging-rate data exists in humans. Animal lifespan studies show promise but don't translate reliably to humans. Sirtuin activation in humans remains largely theoretical.
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