Prolon Next Gen is a 5-day fasting-mimicking diet (FMD) with ready-to-eat organic soups, nut bars, snacks, and supplements designed to keep you in a fasting state while nourishing your body. The only program with landmark research demonstrating it triggers autophagy—a cellular renewal process—in humans. Three consecutive monthly cycles may reduce biological age by ~2.5 years.
Multiple observational studies and small RCTs show FMD can improve metabolic markers (fasting glucose, insulin, lipids) and reduce inflammation markers in humans. However, evidence for longevity or disease prevention remains limited; most trials are short-term (weeks to months), underpowered, or lack long-term follow-up. The mechanistic rationale is sound, but human outcome data—especially for aging, cancer, or cardiovascular disease prevention—is sparse.
A fasting-mimicking diet (FMD) is a low-calorie, plant-based eating protocol (typically 800–1100 kcal/day for 5 days) designed to trigger metabolic shifts similar to prolonged fasting—including autophagy activation, mitochondrial renewal, and shifts in growth-factor signaling (IGF-1, mTOR)—while allowing some food intake to improve adherence and reduce muscle loss compared to water fasting.
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Observational
“Calorie restriction or changes in dietary composition can enhance healthy aging, but the inability of most subjects to adhere to chronic and extreme diets, as well as potentially adverse effects, limits their application.”
“In healthy individuals, short cycles of a fasting-mimicking diet (FMD) decrease systemic inflammatory markers and improve metabolic health.”
“OBJECTIVES: The aim of this study was to test the feasibility of a fasting-mimicking diet on the systemic and periodontal response following non-surgical periodontal therapy.”
“This review examines the potential of fasting-mimicking diets (FMDs) in preventing and treating Alzheimer's disease (AD).”
No large RCTs demonstrating clinical benefit (e.g., mortality reduction, cancer prevention, or lifespan extension) in humans. Most published work is observational or involves small, short-duration interventions. Muscle loss during FMD cycles has been reported in some studies. Adherence is challenging; dropout rates in trials are often high. Long-term safety and optimal frequency of FMD cycles are not well established. Animal studies (mice, yeast) show robust autophagy and lifespan extension, but human translation remains uncertain.
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