Our Super Omega-3 EPA/DHA formula is made with Pure+, an IFOS™ certified fish oil that delivers EPA and DHA fatty acids to promote heart health, brain health and beyond. Our Super Omega-3 formula is augmented with polyphenols from olive extract and sesame lignans.
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Multiple meta-analyses and RCTs confirm EPA/DHA supplementation reduces triglycerides and supports cardiovascular health; the REDUCE-IT trial (2018) showed high-dose EPA alone reduced cardiovascular events in statin-treated patients with elevated triglycerides. Sesame lignans are less rigorously studied but mechanistic evidence supports modest enhancement of omega-3 absorption and antioxidant effects.
EPA/DHA (eicosapentaenoic and docosahexaenoic acid), long-chain omega-3 fatty acids from fish oil, integrate into cell membranes and modulate inflammatory pathways, prostaglandin synthesis, and triglyceride metabolism. Sesame lignans (lignin compounds) may enhance omega-3 bioavailability and reduce lipid peroxidation. Olive extract polyphenols provide antioxidant activity and support endothelial function.
Meta-analysis
“BACKGROUND: Omega-3 polyunsaturated fatty acids from oily fish (long-chain omega-3 (LCn3)), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)), as well as from plants (alpha-linolenic acid (ALA)) may benefit cardiovascula”
“BACKGROUND: Researchers have suggested that omega-3 polyunsaturated fatty acids from oily fish (long-chain omega-3 (LCn3), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)), as well as from plants (alpha-linolenic acid (”
“OBJECTIVE: Hypertriglyceridemia is associated with cardiovascular disease in diabetes.”
“Author information: (1)Center on Aging and Mobility, University Hospital Zurich, City Hospital Waid & Triemli and University of Zurich, Zurich, Switzerland.”
The product combines three ingredients, each with different evidence bases. Sesame lignans and olive extract are not individually validated in human trials at these doses; the primary evidence here rests on EPA/DHA alone. High-dose fish oil may increase bleeding risk in some populations and can interact with anticoagulants. Recent meta-analyses (2022-2023) show mixed results on omega-3 and all-cause mortality in primary prevention (healthy populations without prior cardiovascular disease), though secondary prevention benefits remain stronger.
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