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Supplement$29.25· checked May◆ Editor's Pick

Super Omega-3 EPA/DHA Fish Oil, Sesame Lignans & Olive Extract, 120 softgels

Our Super Omega-3 EPA/DHA formula is made with Pure+, an IFOS™ certified fish oil that delivers EPA and DHA fatty acids to promote heart health, brain health and beyond. Our Super Omega-3 formula is augmented with polyphenols from olive extract and sesame lignans.

@LZ·just now·via lifeextension.com
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Evidence
5/5

Multiple meta-analyses and RCTs confirm EPA/DHA supplementation reduces triglycerides and supports cardiovascular health; the REDUCE-IT trial (2018) showed high-dose EPA alone reduced cardiovascular events in statin-treated patients with elevated triglycerides. Sesame lignans are less rigorously studied but mechanistic evidence supports modest enhancement of omega-3 absorption and antioxidant effects.

Mechanism

EPA/DHA (eicosapentaenoic and docosahexaenoic acid), long-chain omega-3 fatty acids from fish oil, integrate into cell membranes and modulate inflammatory pathways, prostaglandin synthesis, and triglyceride metabolism. Sesame lignans (lignin compounds) may enhance omega-3 bioavailability and reduce lipid peroxidation. Olive extract polyphenols provide antioxidant activity and support endothelial function.

Best evidence type

Meta-analysis

Sources
Caveats

The product combines three ingredients, each with different evidence bases. Sesame lignans and olive extract are not individually validated in human trials at these doses; the primary evidence here rests on EPA/DHA alone. High-dose fish oil may increase bleeding risk in some populations and can interact with anticoagulants. Recent meta-analyses (2022-2023) show mixed results on omega-3 and all-cause mortality in primary prevention (healthy populations without prior cardiovascular disease), though secondary prevention benefits remain stronger.

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