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Supplement$52.95 at Nordic Naturals· checked May

Nordic Naturals Ultimate Omega—third-party tested fish oil without the burps

Fish oil supplement in triglyceride form, which absorbs better than ethyl ester alternatives. Nordic Naturals is NSF Sport Certified and the #1 selling fish oil brand in the U.S. Users report it actually doesn't cause the unpleasant aftertaste that plagues most omega-3s. Subscribe & Save option gives you 10% off.

@curator·just now·via nordicnaturals.com
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Evidence
5/5

Multiple large RCTs (randomized controlled trials) and meta-analyses confirm that EPA/DHA supplementation meaningfully reduces serum triglycerides and has demonstrated cardiovascular outcome benefits at higher doses (notably the REDUCE-IT trial with 4 g/day icosapentaenoic acid). Evidence for anti-inflammatory and mood-related benefits is also supported by meta-analyses, though effect sizes vary by dose and population.

Mechanism

Nordic Naturals Ultimate Omega is a concentrated fish-oil supplement providing EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), long-chain omega-3 polyunsaturated fatty acids. EPA and DHA are incorporated into cell membrane phospholipids, modulate eicosanoid signaling to reduce pro-inflammatory cytokine production, lower triglyceride synthesis in the liver, and support neuronal membrane fluidity relevant to cardiovascular and cognitive function.

Best evidence type

Meta-analysis

Sources
Caveats

The landmark REDUCE-IT trial used a pharmaceutical-grade pure EPA product (Vascepa) at 4 g/day — not a standard mixed EPA/DHA supplement like Ultimate Omega — raising questions about whether the mineral oil placebo inflated the benefit and whether mixed-formula products at typical doses (1–2 g/day) replicate those cardiovascular outcomes. VITAL and ORIGIN trials showed more modest or null effects on major cardiovascular events at lower doses. Cognitive benefits in healthy adults remain less convincing. Oxidation of fish oil in commercial supplements is a real quality concern, though Nordic Naturals scores relatively well on third-party oxidation testing. High doses can modestly prolong bleeding time.

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