Supplement$24.95 at Double Wood Supplements

50 mg apigenin capsules, the Huberman-approved sleep dose in a two-month supply

A chamomile-derived bioflavonoid in 50 mg capsules—the exact dose Andrew Huberman popularized for sleep support. Take one before bed with dietary fat, or one in the morning with breakfast for daytime stress support. Each bottle contains 120 capsules for a two-month supply. Third-party tested for identity, potency, and heavy metals (lead, cadmium, arsenic, mercury). Soy-free, gluten-free, vegan.

Evidence

3/5

Apigenin shows consistent in-vitro and animal evidence for anti-inflammatory and antioxidant effects, with some human observational data linking dietary flavonoid intake to reduced cardiovascular and cognitive decline risk. However, no large RCTs of apigenin supplementation in humans exist, and bioavailability is poor (most ingested apigenin is not absorbed). The gap between mechanistic promise and human-trial evidence is substantial.

Mechanism

Apigenin is a flavonoid found in plants (chamomile, parsley, celery) that acts as an antioxidant and modulates inflammatory pathways, including NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling. It may also interact with benzodiazepine receptors and affect circadian rhythm regulation, though the latter mechanism is less established in humans.

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50 mg apigenin capsules, the Huberman-approved sleep dose in a two-month supply

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One of these every Sunday.